A NUMERICAL APPROACH TO ION CHANNEL MODELLING USING WHOLE-CELL VOLTAGE-CLAMP RECORDINGS AND A GENETIC ALGORITHM.

A numerical approach to ion channel modelling using whole-cell voltage-clamp recordings and a genetic algorithm.

The activity of trans-membrane proteins such as ion channels is the essence of neuronal transmission.The currently most accurate method for determining ion channel kinetic mechanisms is single-channel recording and analysis.Yet, the limitations and complexities in interpreting single-channel recordings discourage many physiologists from using them.

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Quick-Response Model for Pre- and Post-Disaster Evacuation and Aid Distribution: The Case of the Tula River Flood Event

Background: In the context of humanitarian logistics, efficiently evacuating people from disaster-stricken areas is a complex challenge.This study focuses on the Tula River region in Hidalgo, Mexico, exploring the evacuation and support of individuals in temporary shelters.Despite the fact that the topic tillman 750m has been addressed in the liter

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